Firas S Zetoune Selected Research

Anaphylatoxin C5a Receptor

1/2020	Role of Complement and Histones in Sepsis.
1/2016	Complement Destabilizes Cardiomyocyte Function In Vivo after Polymicrobial Sepsis and In Vitro.
2/2015	Cutting edge: critical role for C5aRs in the development of septic lymphopenia in mice.
12/2013	Extracellular histones are essential effectors of C5aR- and C5L2-mediated tissue damage and inflammation in acute lung injury.
7/2011	Complement dependency of cardiomyocyte release of mediators during sepsis.
11/2009	Attenuation of IgG immune complex-induced acute lung injury by silencing C5aR in lung epithelial cells.
5/2008	Functional roles for C5a receptors in sepsis.
2/2004	Regulatory role of C5a in LPS-induced IL-6 production by neutrophils during sepsis.
10/2003	Neutrophil C5a receptor and the outcome in a rat model of sepsis.
7/2002	Increased C5a receptor expression in sepsis.

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Firas S Zetoune Research Topics

Disease

31	Sepsis (Septicemia) 11/2020 - 06/2002
10	Acute Lung Injury 01/2017 - 03/2005
9	Inflammation (Inflammations) 01/2017 - 10/2003
5	Cardiomyopathies (Cardiomyopathy) 01/2020 - 01/2006
4	Infections 12/2014 - 10/2003
3	Endotoxemia 04/2013 - 12/2011
2	Shock 12/2014 - 04/2012
2	Edema (Dropsy) 12/2013 - 11/2009
2	Bacteremia 10/2008 - 07/2008
2	Pneumonia (Pneumonitis) 10/2007 - 10/2003
1	Blister (Bulla) 01/2018
1	Lymphopenia (Lymphocytopenia) 02/2015
1	Neoplasms (Cancer) 05/2013
1	Hypothermia 10/2011
1	Hemorrhage 11/2009
1	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 06/2006
1	Autoimmune Diseases (Autoimmune Disease) 06/2006
1	Pulmonary Edema 03/2005
1	Lung Injury 03/2005

Drug/Important Bio-Agent (IBA)

13	Complement System Proteins (Complement)IBA 11/2020 - 01/2003
11	Anaphylatoxin C5a ReceptorIBA 01/2020 - 06/2002
9	Histones (Histone)IBA 11/2020 - 12/2013
9	CytokinesIBA 01/2020 - 07/2006
6	Antigen-Antibody Complex (Immune Complex)IBA 01/2014 - 03/2005
6	Immunoglobulin G (IgG)IBA 01/2014 - 03/2005
5	AnaphylatoxinsIBA 11/2020 - 10/2002
5	ChemokinesIBA 01/2020 - 07/2008
5	Interleukin-17 (Interleukin 17)IBA 04/2013 - 07/2008
3	Messenger RNA (mRNA)IBA 01/2016 - 07/2002
3	CatecholaminesIBA 01/2014 - 10/2007
3	Interleukin-6 (Interleukin 6)IBA 07/2011 - 02/2004
2	Complement C5a (Complement 5a)IBA 01/2017 - 11/2009
2	AlbuminsIBA 01/2017 - 03/2005
2	InflammasomesIBA 12/2016 - 06/2014
2	Proteins (Proteins, Gene)FDA Link 01/2016 - 03/2005
2	Interleukin-23 (Interleukin 23)IBA 05/2013 - 04/2012
2	LipopolysaccharidesIBA 05/2013 - 06/2008
2	AntibodiesIBA 07/2008 - 06/2005
2	CXC ChemokinesIBA 07/2006 - 10/2003
2	Peroxidase (Myeloperoxidase)IBA 03/2005 - 10/2003
1	Complement Membrane Attack Complex (Membrane Attack Complex)IBA 11/2020
1	eculizumab FDA Link 11/2020
1	Pharmaceutical PreparationsIBA 01/2020
1	Biological ProductsIBA 01/2017
1	Adenosine Triphosphatases (ATPase)IBA 01/2016
1	Sodium-Calcium ExchangerIBA 01/2016
1	Sarcoplasmic Reticulum Calcium-Transporting ATPasesIBA 01/2016
1	Fluorescein-5-isothiocyanate (FITC)IBA 03/2015
1	Interleukin-27 (Interleukin 27)IBA 12/2014
1	Clodronic Acid (Clodronate)IBA 12/2014
1	Interleukin-10 (Interleukin 10)IBA 12/2014
1	Liposomes (Liposome)IBA 12/2014
1	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 07/2013
1	zonulinIBA 06/2013
1	salicylhydroxamic acid (SHAM)IBA 04/2013
1	GlucocorticoidsIBA 04/2013
1	Hormones (Hormone)IBA 04/2013
1	Adrenergic Agonists (Adrenergic Receptor Agonist)IBA 05/2012
1	Adrenergic Receptors (Adrenergic Receptor)IBA 05/2012
1	Urea (Carbamide)FDA LinkGeneric 10/2011
1	NitrogenIBA 10/2011
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 10/2011
1	Type I Tumor Necrosis Factor ReceptorsIBA 07/2011
1	Neutralizing AntibodiesIBA 07/2011
1	Complement C3 (C3 Complement)IBA 10/2008
1	HMGB1 Protein (HMG1)IBA 05/2008
1	EnzymesIBA 10/2007
1	Macrophage Migration-Inhibitory FactorsIBA 07/2004
1	LigandsIBA 10/2003
1	NF-kappa B (NF-kB)IBA 08/2003
1	CaspasesIBA 06/2002
1	Annexin A5IBA 06/2002

Therapy/Procedure

23	Ligation 01/2018 - 06/2002
23	Punctures 01/2018 - 06/2002
1	Intravenous Infusions 03/2015